Our published research

“Nitrogen-Rich Carbon Dots as Effective Catalysts in the 1,4-Reduction of ,-Unsaturated Aldehydes via Ion Pair Asymmetric Nano-Organocatalysis ” A. Carioscia, E. Cocco, M. E. Casacchia, G. Gentile, M. Mamone, G. Giorgianni, E. Incerto, M. Prato, F. Pesciaioli, G. Filippini, A. Carlone, ACS Catalysis, 2024, 14, 13429−13438.

“New polymeric disulfonimide for heterogeneous silicon Lewis acid catalysis” G. Giorgianni, M. E. Casacchia, P. C. Ricci, S. Di Muzio, A. Lazzarini, A. Carlone, F. Pesciaioli, Synlett, 2024, just accepted.

“Stereoselective reactions promoted by alkali metal salts of phosphoric acid organocatalysts” E. Cocco, A. Antenucci, A. Carlone, P. Manini, F. Pesciaioli, S. Dughera, ChemCatChem, 2024, e202400328.

“Catalytic Access to Diastereometrically Pure Four- and Five-Membered Silyl-Heterocycles Using Transborylation” D. R. Willcox, E. Cocco, G. S. Nichol, A. Carlone, S. Thomas Angew. Chem. Int. Ed., 2024, e202401737.

“Piers–Rubinsztajn reaction to unlock an 8-step synthesis of 7-hydroxy cannabidiol” E. Cocco, D. Iapadre, A. Brusa, P. Allegrini, S. P. Thomas, F. Pesciaioli, A. Carlone, RSC Adv., 2024, 14, 2741-2744.

“Acetaldehyde in the Enders triple cascade reaction via acetaldehyde dimethyl acetal” A. Brusa, D. Iapadre, M. E. Casacchia, A. Carioscia, G. Giorgianni, G. Magagnano, F. Pesciaioli, A. Carlone, Beilstein J. Org. Chem., 2023, 19, 1243-1250.

Part of the thematic issue: Catalytic multi-step domino and one-pot reactions, Guest Editor: S. Tsogoeva.

“A Sustainable and Catalytic Synthesis of Dibenzosuberone” V. Nori, F. Della Penna, E. Cocco, S. Mantegazza, G. Razzetti, G. Quattrocchi, F. Pesciaioli, A. Carlone, ChemCatChem, 2023, e202300642.

Part of the Topical Collection: Catalysts in Industry

“Organocatalytic synthesis of γ-amino acids precursors via masked acetaldehyde under micellar catalysis” M. E. Casacchia, G. Giorgianni, E. Allegritti, L. Giansanti, A. Carlone, F. Pesciaioli, SynOpen, 2023, 07 (01), 29-32.

Highlighted on SYNFORM

Elected SynOpen Best Paper 2023 by the Editorial Board

“Synergistic Organo-Organocatalysis” F. Pesciaioli, V. Nori, A. Sinibaldi, A. Carlone, in Asymmetric Organocatalysis: New Strategies, Catalysts, and Opportunities (Eds.: Ł. Albrecht, A. Albrecht, L. Dell’Amico), WILEY‐VCH GmbH, 2023, 271-318.

“HistoEnder: A 3D printer-based histological slide autostainer that retains 3D printer functions” M. Ponzetti G. C. R. Devarapu, N. Rucci, A. Carlone, V. Saggiomo, HardwareX, 2022, 12, e00370.

“Asymmetric Organocatalysis — A Powerful Technology Platform for Academia and Industry: Pregabalin as a Case Study” G. Giorgianni, L. Bernardi, F. Fini, F. Pesciaioli, F. Secci, A. Carlone, Catalysts, 2022, 12, 912.

“Insights into the reactivity of 2-hydroxycyclobutanones with thiols corroborated by quantum chemical DFT investigations, NMR and Raman analysis” S. Porcu, M. C. Cabua, V. Velichko, J.-P. Baltaze, A. Frongia, C. M. Carbonaro, P. C. Ricci, D. F. Parsons, A. Carlone, F. Secci, Synthesis, 2022, 54(24), 5423-5433.

“Synergistic strategies in Aminocatalysis” A. Del Vecchio, A. Sinibaldi, V. Nori, G. Giorgianni, G. Di Carmine, F. Pesciaioli, Chem. Eur. J., 2022, 28, e202200818.

“Insights into substituent effects of benzaldehyde derivatives in a heterogeneous organocatalyzed aldol reaction” G. Di Carmine, F. Pesciaioli, S. Wang, A. Sinibaldi, G. Giorgianni, C. M. A. Parlett, A. Carlone, C. D’Agostino, ChemCatChem, 2022, 14, e202200405.

“DoE-driven development of an organocatalytic enantioselective addition of acetaldehyde to nitrostyrenes in water” V. Nori, A. Sinibaldi, G. Giorgianni, F. Pesciaioli, F. Di Donato, E. Cocco, A. Biancolillo, A. Landa, A. Carlone, Chem. – Eur. J., 2022, 28, e202104524.

“Polycationic Rh–JosiPhos Polymers Supported on Phosphotungstic Acid/Al2O3 by Multiple Electrostatic Attractions” P. Nepal, S. Kalapugama, M. Shevlin, J. R. Naber, L.-C. Campeau, C. Pezzetta, A. Carlone, C. J. Cobley, S. H. Bergens, ACS Catal., 2022, 12, 2034–2044.

“Impact of Design of Experiments in the optimisation of catalytic reactions in academia” V. Nori, A. Sinibaldi, F. Pesciaioli, A. Carlone, Synthesis, 2022, 54, 4246-4256.

Part of the Special Issue ISySyCat21.

“NMR relaxation time measurements of solvent effects in an organocatalysed asymmetric aldol reaction over silica SBA-15 supported proline” G. Di Carmine, L. S. M. Forster, S. Wang, C. Parlett, A. Carlone, C. D’Agostino, React. Chem. Eng., 2022, 7, 269-274.

“Boron-Based Lewis Acid Catalysis: Challenges and Perspectives” V. Nori, F. Pesciaioli, A. Sinibaldi, G. Giorgianni, A. Carlone, Catalysts, 2022, 12, 1, 5.

“Preparation of a pharmaceutical intermediate” F. Della Penna, V. Nori, F. Pesciaioli, A. Carlone, EP4119536B1 / US20230053759A1.

“Asymmetric organocatalysis and continuous chemistry for an efficient and cost competitive process to pregabalin” A. Carlone, C. J. Cobley, L. Bernardi, P. McCormack, T. Warr, S. Oruganti, Org. Process Res. Dev., 2021, 25, 12, 2795–2805.

“Turning renewable feedstocks into a valuable and efficient punctually chiral phosphate salt catalyst” A. Antenucci, M. Messina, M. Bertolone, M. Bella, A. Carlone, R. Salvio, S. Dughera, Asian J. Org. Chem., 2021, 10, 12, 3279-3284.

“Asymmetric organocatalysis accelerated via self-assembled minimal structures” A. Sinibaldi, F. Della Penna, M. Ponzetti, F. Fini, S. Marchesan, A. Baschieri, F. Pesciaioli, A. Carlone, Eur. J. Org. Chem., 2021, 39, 5403-5406.

Part of the Organocatalysis special collection.
Highlighted on Chemistry world “Supramolecular peptide fibres accelerate Michael reaction“.
Featured as the Cover Issue, Eur. J. Org. Chem., 2021, 39, 5387.
Animated version of the cover here.

“Enantioselective organocatalytic approaches to active pharmaceutical ingredients – selected industrial examples” A. Carlone, L. Bernardi, in Organocatalysis – Stereoselective Reactions and Applications in Organic Synthesis (Ed.: M. Benaglia), De Gruyter, Berlin, Boston, 2021, 401-434.

“Industrial Relevance of Asymmetric Organocatalysis in the Preparation of Chiral Amine Derivatives” L. Bernardi, A. Carlone, F. Fini, in Methodologies in Amine Synthesis (Eds.: A. Ricci, L. Bernardi), Wiley-VCH, Weinheim, 2021, 187–242.

“Organocatalyzed Michael Addition to Nitroalkenes via Masked Acetaldehyde” G. Giorgianni, V. Nori, A. Baschieri, L. Palombi, A. Carlone, Catalysts, 2020, 10, 1296.

“Iridium(III) Complexes with Fluorinated Phenyl-tetrazoles as Cyclometalating Ligands: Enhanced Excited-State Energy and Blue Emission” A. Baschieri, L. Sambri, A. Mazzanti, A. Carlone, F. Monti, N. Armaroli, Inorg. Chem., 2020, 59, 16238−16250.

“Triarylborane Catalysed N-Alkylation of Amines with Aryl Esters” V. Nori, A. Dasgupta, R. Babaahmadi, A. Carlone, A. Ariafard, R. Melen, Catal. Sci. Technol., 2020, 25, 100387.

“Advancements in the recycling of organocatalysts: From classical to alternative approaches” T. Fulgheri, F. Della Penna, A. Baschieri, A. Carlone, Current Opinion in Green and Sustainable Chemistry, 2020, 25, 100387.

“Palladium-catalyzed regio- and stereoselective synthesis of aryl and 3-indolyl-substituted 4-methylene-3,4-dihydroisoquinolin-1(2H)-ones” V. Nori, A. Arcadi, A. Carlone, F. Marinelli, M. Chiarini, Beilstein J. Org. Chem., 2020, 16, 1084–1091.

“Organocatalysis and Beyond: Activating Reactions with Two Catalytic Species” A. Sinibaldi, V. Nori, A. Baschieri, F. Fini, A. Arcadi, A. Carlone, Catalysts, 2019, 9, 928.

“Influence of structurally related micelle forming surfactants on the antioxidant activity of natural substances” S. Battista, P. Campitelli, A. Carlone, L. Giansanti, Chemistry and Physics of Lipids, 2019, 225, 104818.

“A technology platform to chiral amines: selected examples in asymmetric organocatalysis” A. Carlone, F. Fini, V. Nori, A. Sinibaldi, Chimica Oggi/Chemistry Today, 2019, 37, 4, 17-20.

“Enantioselective organocatalytic approaches to active pharmaceutical ingredients – selected industrial examples” A. Carlone, L. Bernardi, Physical Sciences Reviews, 2019, 4, 8, 20180097.

“Diverse exploitation of Brønsted acid catalysts – paving the way for simple entries to enantioenriched amines” A. Carlone, L. Bernardi, Org. Chem. Front., 2017, 4, 1651-1654.

“Process for preparation of eribulin and intermediates thereof” S. A. Warren, M. E. Fox, G. A. Meek, A. Carlone, L. Bernardi P. D. de Koning, J. A. Peterson, P. G. Cozzi, D. Basu, S. Sai, K. Sarvesh, A. K. Mandal, R. Bandichhor, V. H. Dahanukar, R. W. M. Davidson, WO2017064627A2.

“An Autonomous Chemically Fuelled Small-Molecule Motor” M. R. Wilson, J. Solà, A. Carlone, S. M. Goldup, N. Lebrasseur, D. A. Leigh, Nature, 2016, 534, 235-240.

“Organocatalytic Asymmetric Conjugate Additions to Cyclopent-1-enecarbaldehyde: A Critical Assessment of Organocatalytic Approaches towards the Telaprevir Bicyclic Core” L. Bernardi, M. Fochi, R. Carbone, A. Martinelli, M. E. Fox, C. J. Cobley, B. Kandagatla, S. Oruganti, V. H. Dahanukar, A. Carlone*, Chem. – Eur. J., 2015, 21, 19208–19222.

“Kinetic Resolution of Oxazinones: Rational Exploration of Chemical Space through the Design of Experiments” P. Renzi, C. Kronig, A. Carlone, S. Eröksüz, A. Berkessel, M. Bella, Chem. – Eur. J., 2014, 20, 11768-11775.

“Process for preparation of pregabalin” A. Carlone, L. Bernardi, A. Warr, P. de Koning, R. Rajan IN2013CH04788A, 2013.

“A Three-Compartment Chemically-Driven Molecular Information Ratchet” A. Carlone, S. M. Goldup, N. Lebrasseur, D. A. Leigh, A. Wilson, J. Am. Chem. Soc., 2012, 134, 8321-8323.

“A Rotaxane-Based Switchable Organocatalyst” V. Blanco, A. Carlone, K. D. Hänni, D. A. Leigh, B. Lewandowski, Angew. Chem. Int. Ed., 2012, 51, 5166-5169.

“A Small Molecule That Walks Non-Directionally Along a Track Without External Intervention” A. G. Campaña, A. Carlone, K. Chen, D. T. F. Dryden, D. A. Leigh, U. Lewandowska, K. M. Mullen, Angew. Chem. Int. Ed., 2012, 51, 5480-5483.

“Aminocatalytic Enantioselective anti-Mannich Reaction of Aldehydes with in Situ Generated N-Cbz and N-Boc Imines” C. Gianelli, L. Sambri, A. Carlone, G. Bartoli, P. Melchiorre, Angew. Chem. Int. Ed. 2008, 47, 8700-8702.

“Asymmetric Aminocatalysis—Gold Rush in Organic Chemistry” P. Melchiorre, M. Marigo, A. Carlone, G. Bartoli, Angew. Chem. Int. Ed., 2008, 47, 6138-6171.

“Quaternary Stereogenic Carbon Atoms in Complex Molecules by an Asymmetric, Organocatalytic, Triple-Cascade Reaction” O. Penon, A. Carlone, A. Mazzanti, M. Locatelli, L. Sambri, G. Bartoli, P. Melchiorre, Chem. – Eur. J., 2008, 14, 4788-4791.

“Organocatalytic Asymmetric Sulfa-Michael Addition to α,β -Unsaturated Ketones” P. Ricci, A. Carlone, M. Bosco, L. Sambri, G. Bartoli, P. Melchiorre, Adv. Synth. Cat., 2008, 350, 49-53.

“Magnesium perchlorate as efficient Lewis acid for the Knoevenagel condensation between β-diketones and aldehydes” G. Bartoli, M. Bosco, A. Carlone, R. Dalpozzo, P. Galzerano, P. Melchiorre, L. Sambri, Tetrahedron Letters, 2008, 49, 2555-2557.

“Organocatalytic Asymmetric β-Hydroxylation of α,β-Unsaturated Ketones” A. Carlone, G. Bartoli, M. Bosco, F. Pesciaioli, P. Ricci, L. Sambri, P. Melchiorre, Eur. J. Org. Chem., 2007, 33, 5492-5495.

“Organocatalytic Asymmetric α-Selenenylation of Aldehydes” M. Tiecco, A. Carlone, S. Sternativo, F. Marini, G. Bartoli, P. Melchiorre, Angew. Chem. Int. Ed. 2007, 46, 6882-6885.

“Organocatalytic Asymmetric Hydrophosphination of α,β-Unsaturated Aldehydes” A. Carlone, G. Bartoli, M. Bosco, L. Sambri, P. Melchiorre, Angew. Chem. Int. Ed., 2007, 46, 4504-4506.

“A New Approach for an Organocatalytic Multicomponent Domino Asymmetric Reaction” A. Carlone, S. Cabrera, M. Marigo, K. A. Jørgensen, Angew. Chem. Int. Ed., 2007, 46, 1101-1104.

“Organocatalytic Asymmetric Friedel-Crafts Alkylation of Indoles with Simple α,β-Unsatured Ketones” G. Bartoli, M. Bosco, A. Carlone, F. Pesciaioli, L. Sambri, P. Melchiorre, Org. Lett., 2007, 9, 1403-1405.

“Organocatalytic asymmetric hydrophosphination of nitroalkenes” G. Bartoli, M. Bosco, A. Carlone, M. Locatelli, A. Mazzanti, L. Sambri, P. Melchiorre, Chem. Commun., 2007, 722-724.

“Magnesium Perchlorate as Efficient Lewis Acid: A Simple and Convenient Route to 1,4-Dihydropyridines” G. Bartoli, K. Babiuch, M. Bosco, A. Carlone, P. Galzerano, P. Melchiorre, L. Sambri, Synlett, 2007, 2897-2901.

“Reaction of Dicarbonates with Carboxylic Acids Catalyzed by Weak Lewis Acids: General Method for the Synthesis of Anhydrides and Esters” G. Bartoli, M. Bosco, A. Carlone, R. Dalpozzo, E. Marcantoni, P. Melchiorre, L. Sambri, Synthesis, 2007, 3489-3496.

“A simple asymmetric organocatalytic approach to optically active cyclohexenones” A. Carlone, M. Marigo, C. North, A. Landa, K. A. Jørgensen, Chem. Commun., 2006, 4928-4930.

“Organocatalytic Asymmetric Conjugate Addition of 1,3-Dicarbonyl Compounds to Maleimides” G. Bartoli, M. Bosco A. Carlone, A. Cavalli, M. Locatelli, A. Mazzanti, P. Ricci, L. Sambri, P. Melchiorre, Angew. Chem. Int. Ed., 2006, 45, 4966-4970.

“tert-Butyl Ethers: Renaissance of an Alcohol Protecting Group. Facile Cleavage with Cerium(III) Chloride/Sodium Iodide” G. Bartoli, M. Bosco, A. Carlone, M. Locatelli, E. Marcantoni, P. Melchiorre, L. Sambri, Adv. Synth. Cat., 2006, 348, 905-910.

“A New, Mild, General and Efficient Route to Aryl Ethyl Carbonates in Solvent-Free Conditions Promoted by Magnesium Perchlorate” G. Bartoli, M. Bosco, A. Carlone, M. Locatelli, E. Marcantoni, P. Melchiorre, P. Palazzi, L. Sambri, Eur. J. Org. Chem., 2006, 4429-4434.

“The First Simple Method of Protection of Hydroxy Compounds as their O-Boc Derivatives under Lewis Acid Catalysis” G. Bartoli, M. Bosco, A. Carlone, R. Dalpozzo, M. Locatelli, P. Melchiorre, P. Palazzi, L. Sambri, Synlett, 2006, 2104-2108.

“Alcohols and Di-tert-butyl Dicarbonate: How the Nature of the Lewis Acid Catalyst May Address the Reaction to the Synthesis of tert-Butyl Ethers” G. Bartoli, M. Bosco, A. Carlone, R. Dalpozzo, M. Locatelli, P. Melchiorre, L. Sambri, J. Org. Chem. 2006, 71, 9580-9588.

“Organocatalytic Asymmetric α-Halogenation of 1,3-Dicarbonyl Compounds” G. Bartoli, M. Bosco, A. Carlone, M. Locatelli, P. Melchiorre, L. Sambri, Angew. Chem. Int. Ed., 2005, 44, 6219-6222.

“Direct Catalytic Synthesis of Enantiopure 5-Substituted Oxazolidinones from Racemic Terminal Epoxides” G. Bartoli, M. Bosco, A. Carlone, M. Locatelli, P. Melchiorre, L. Sambri, Org. Lett., 2005, 1983-1985.

“Asymmetric Catalytic Synthesis of Enantiopure N-Protected 1,2-Amino Alcohols” G. Bartoli, M. Bosco, A. Carlone, M. Locatelli, P. Melchiorre, L. Sambri, Org. Lett., 2004, 3973-3975.